When you have been beaten down by it
Nūḥ ﷺ after centuries of being mocked, in six words.
فَدَعَا رَبَّهُۥٓ أَنِّى مَغْلُوبٌ فَٱنتَصِرْ
…annī maghlūbun fa-ntaṣir.
So he invoked his Lord, "Indeed, I am overpowered, so help."
Where this comes from
Nine hundred and fifty years of calling people who would not listen. When it finally broke, this is all he said. It is one of the shortest supplications in the Qur'an.
Source
The Qur'an · 54:10
Qur'an
- Qur'anic text in the Uthmani script via Quran.com; translation: Saheeh International